Target：Ebi3

Fields：Cytokine-cytokine receptor interaction;Th17 cell differentiation

Gene Name：EBI3

Protein Name：Interleukin-27 subunit beta

Human Gene Id：10148

Human Swiss Prot No：Q14213

Mouse Gene Id：50498

Mouse Swiss Prot No：O35228

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human EBI3. AA range:101-150

Specificity：Ebi3 Polyclonal Antibody detects endogenous levels of Ebi3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：EBI3;IL27B;Interleukin-27 subunit beta;IL-27 subunit beta;IL-27B;Epstein-Barr virus-induced gene 3 protein;EBV-induced gene 3 protein

Observed Band(KD)：25kD

Background： This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008],

Function：function:Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.,induction:By EBV.,online information:Interleukin-27 entry,similarity:Belongs to the

Subcellular Location：Secreted .

Expression： B-cell,Pancreas,