Target：EAT-2

Fields：Natural killer cell mediated cytotoxicity

Gene Name：SH2D1B

Protein Name：SH2 domain-containing protein 1B

Human Gene Id：117157

Human Swiss Prot No：O14796

Mouse Swiss Prot No：O35324

Immunogen：The antiserum was produced against synthesized peptide derived from human SH2D1B. AA range:71-120

Specificity：EAT-2 Polyclonal Antibody detects endogenous levels of EAT-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SH2D1B;EAT2;SH2 domain-containing protein 1B;EWS/FLI1-activated transcript 2;EAT-2

Molecular Weight(Da)：15kD

Background： By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008],

Function：function:Plays a role in controlling signal transduction through at least four receptors, CD84, CD150, CD229 and CD244, expressed on the surface of professional antigen-presenting cells.,similarity:Contains 1 SH2 domain.,subunit:Binds to the phosphorylated receptors CD84, CD150, CD229 and CD244. Does not bind to non-phosphorylated CD150.,

Subcellular Location：intracellular,cytosol,

Expression： Leukocyte,Lung,Spleen,