Target：E2F8

Gene Name：E2F8

Protein Name：Transcription factor E2F8 (E2F-8)

Human Gene Id：79733

Human Swiss Prot No：A0AVK6

Mouse Swiss Prot No：Q58FA4

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：E2F8 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：95kD

Background： This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012],

Function：domain:Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer.,function:Along with E2F7, inhibitor of E2F-dependent transcription. Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Directly represses E2F1 transcription. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Belongs to the E2F/DP family.,subunit:Forms heterodimers with E2F7 and, to a lesser extent, homodimers. Dimerization is important for DNA binding.,

Subcellular Location：Nucleus .

Expression： Lung,Mammary gland,Skin,Testis,