Target：E2F7

Gene Name：E2F7

Protein Name：Transcription factor E2F7 (E2F-7)

Human Gene Id：144455

Human Swiss Prot No：Q96AV8

Mouse Swiss Prot No：Q6S7F2

Immunogen：Synthesized peptide derived from human protein . at AA range: 560-640

Specificity：E2F7 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：100kD

Background： E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008],

Function：domain:Both DNA-binding domains are required for DNA-binding and are proposed to form an intramolecular structure that is similar to the winged helix structure of the E2F-DP heterodimer.,function:Along with E2F8, inhibitor of E2F-dependent transcription that is important for the control of the E2F1-TP53 apoptotic pathway. Directly represses E2F1 transcription (By similarity). Binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession.,similarity:Belongs to the E2F/DP family.,subunit:Forms homodimers and, to a lesser extent, heterodimers with E2F8. Dimerization is important for DNA binding.,

Subcellular Location：Nucleus .