Target：DZIP3

Gene Name：DZIP3

Protein Name：E3 ubiquitin-protein ligase DZIP3

Human Gene Id：9666

Human Swiss Prot No：Q86Y13

Mouse Swiss Prot No：Q7TPV2

Immunogen：The antiserum was produced against synthesized peptide derived from human DZIP3. AA range:681-730

Specificity：DZIP3 Polyclonal Antibody detects endogenous levels of DZIP3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DZIP3;KIAA0675;E3 ubiquitin-protein ligase DZIP3;DAZ-interacting protein 3;RNA-binding ubiquitin ligase of 138 kDa;hRUL138

Observed Band(KD)：140kD

Background：function:E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.,pathway:Protein modification; protein ubiquitination.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with DAZ proteins.,tissue specificity:Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.,

Function：function:E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.,pathway:Protein modification; protein ubiquitination.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with DAZ proteins.,tissue specificity:Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.,

Subcellular Location：Cytoplasm .

Expression：Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.