Target：Dynein LC 1

Fields：Amyotrophic lateral sclerosis;Huntington disease;Pathways of neurodegeneration - multiple diseases

Gene Name：DNAL1

Protein Name：Dynein light chain 1 axonemal

Human Gene Id：83544

Human Swiss Prot No：Q4LDG9

Mouse Gene Id：105000

Mouse Swiss Prot No：Q05A62

Immunogen：The antiserum was produced against synthesized peptide derived from human DNAL1. AA range:121-170

Specificity：Dynein LC 1 Polyclonal Antibody detects endogenous levels of Dynein LC 1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DNAL1;C14orf168;Dynein light chain 1; axonemal

Observed Band(KD)：22kD

Background： This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011],

Function：similarity:Belongs to the dynein light chain LC1-type family.,similarity:Contains 4 LRR (leucine-rich) repeats.,subunit:Interacts with DNAH5.,tissue specificity:Expressed in tissues carrying motile cilia such as testis.,

Subcellular Location：Cytoplasm, cytoskeleton, cilium axoneme .

Expression：Expressed in tissues carrying motile cilia such as respiratory epithelia, ependyma and testis.