Target：DYLT1

Fields：Salmonella infection

Gene Name：DYNLT1 TCTEL1 TCTEX-1 TCTEX1

Protein Name：Dynein light chain Tctex-type 1 (Protein CW-1) (T-complex testis-specific protein 1 homolog)

Human Gene Id：6993

Human Swiss Prot No：P63172

Mouse Swiss Prot No：P51807

Rat Swiss Prot No：Q9Z336

Immunogen：Synthesized peptide derived from part region of human protein AA range: 1-50

Specificity：DYLT1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：12kD

Background：dynein light chain Tctex-type 1(DYNLT1) Homo sapiens This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014],

Function：similarity:Belongs to the dynein light chain Tctex-type family.,subunit:Consists of at least two heavy chains and a number of intermediate and light chains. Found in a complex with SCN10A. Interacts with DOC2A, DOC2B and SCN10A (By similarity). Interacts with PVR.,tissue specificity:Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon.,

Subcellular Location：Golgi apparatus . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Localizes to mitotic spindles. .

Expression：Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level).