Target：DPOD4

Fields：DNA replication;Base excision repair;Nucleotide excision repair;Mismatch repair;Homologous recombination

Gene Name：POLD4 POLDS

Protein Name：DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12)

Human Gene Id：57804

Human Swiss Prot No：Q9HCU8

Mouse Swiss Prot No：Q9CWP8

Immunogen：Synthesized peptide derived from part region of human protein AA range: 1-50

Specificity：DPOD4 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：11kD

Background： This gene encodes the smallest subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein enhances the activity of DNA polymerase delta and plays a role in fork repair and stabilization through interactions with the DNA helicase Bloom syndrome protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012],

Function：function:Required for optimal DNA polymerase delta activity. May contribute to PCNA-dependent activity of DNA polymerase delta.,similarity:Belongs to the DNA polymerase delta subunit 4 family.,subunit:Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa. Interacts with WRNIP1. Interacts with POLD4, POLD2, POLD1 and PCNA.,

Subcellular Location：Nucleus . Partially recruited to DNA damage sites within 2 hours following UV irradiation, before degradation. .

Expression： Brain,Cervix,Ovarian carcinoma,Pooled,