Target：GCS-β-2

Gene Name：GUCY1B2

Protein Name：Guanylate cyclase soluble subunit beta-2

Human Gene Id：2974

Human Swiss Prot No：O75343

Rat Gene Id：25206

Rat Swiss Prot No：P22717

Immunogen：The antiserum was produced against synthesized peptide derived from human GCS-beta-2. AA range:53-102

Specificity：GCS-β-2 Polyclonal Antibody detects endogenous levels of GCS-β-2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GUCY1B2;Guanylate cyclase soluble subunit beta-2;GCS-beta-2

Observed Band(KD)：70kD

Background：Nitric oxide-sensitive guanylyl cyclase is a heterodimeric enzyme consisting of an alpha and a beta subunit. The enzyme converts GTP into the second messenger cGMP and plays a major role in the cardiovascular system as a receptor for nitric oxide. Unlike other guanylyl cyclases, GUCY1B2 contains an 86-amino acid C-terminal extension with a consensus sequence for isoprenylation/carboxymethylation.

Subcellular Location：Cytoplasm.

Expression：Expressed in gastric signet ring cell carcinoma, but not in the normal stomach.