Target：GCP4

Gene Name：TUBGCP4

Protein Name：Gamma-tubulin complex component 4

Human Gene Id：27229

Human Swiss Prot No：Q9UGJ1

Mouse Gene Id：51885

Mouse Swiss Prot No：Q9D4F8

Immunogen：The antiserum was produced against synthesized peptide derived from human TUBGCP4. AA range:191-240

Specificity：GCP4 Polyclonal Antibody detects endogenous levels of GCP4 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TUBGCP4;76P;GCP4;Gamma-tubulin complex component 4;GCP-4;hGCP4;Gamma-ring complex protein 76 kDa;h76p;hGrip76

Observed Band(KD)：76kD

Background： This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015],

Function：function:Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.,similarity:Belongs to the GCP family.,subunit:Gamma-tubulin complex is composed of gamma-tubulin, GCP2, GCP3, GCP4, GCP5 and GCP6.,tissue specificity:Ubiquitously expressed.,

Subcellular Location：Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Expression：Ubiquitously expressed.