Target：Dok-6

Gene Name：DOK6

Protein Name：Docking protein 6

Human Gene Id：220164

Human Swiss Prot No：Q6PKX4

Mouse Gene Id：623279

Mouse Swiss Prot No：Q2MHE5

Immunogen：The antiserum was produced against synthesized peptide derived from human DOK6. AA range:111-160

Specificity：Dok-6 Polyclonal Antibody detects endogenous levels of Dok-6 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DOK6;DOK5L;Docking protein 6;Downstream of tyrosine kinase 6

Observed Band(KD)：43kD

Background：docking protein 6(DOK6) Homo sapiens DOK6 is a member of the DOK (see DOK1; MIM 602919) family of intracellular adaptors that play a role in the RET (MIM 164761) signaling cascade (Crowder et al., 2004 [PubMed 15286081]).[supplied by OMIM, Mar 2008],

Function：domain:PTB domain mediates receptor interaction.,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.,PTM:On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase.,similarity:Belongs to the DOK family. Type B subfamily.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,subunit:Interacts via its PTB domain with phosphorylated RET.,tissue specificity:Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.,

Expression：Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis.