Target：DNJC3

Fields：Protein processing in endoplasmic reticulum;Influenza A

Gene Name：DNAJC3 P58IPK PRKRI

Protein Name：DnaJ homolog subfamily C member 3 (Endoplasmic reticulum DnaJ protein 6) (ERdj6) (Interferon-induced, double-stranded RNA-activated protein kinase inhibitor) (Protein kinase inhibitor of 58 kDa) (Prot

Human Gene Id：5611

Human Swiss Prot No：Q13217

Mouse Swiss Prot No：Q91YW3

Rat Swiss Prot No：Q9R0T3

Immunogen：Synthesized peptide derived from human protein . at AA range: 80-160

Specificity：DNJC3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：55kD

Background： This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010],

Function：domain:The J domain mediates interaction with HSPA8.,function:Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.,induction:Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK.,similarity:Contains 1 J domain.,similarity:Contains 9 TPR repeats.,subunit:Interacts with EIF2AK3 (By similarity) and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK.,tissue specificity:Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.,

Subcellular Location：Endoplasmic reticulum .

Expression：Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.