Target：DNA2

Fields：DNA replication

Gene Name：DNA2 DNA2L KIAA0083

Protein Name：DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent

Human Gene Id：1763

Human Swiss Prot No：P51530

Mouse Swiss Prot No：Q6ZQJ5

Rat Swiss Prot No：D3ZG52

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：DNA2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：116kD

Background： This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014],

Function：function:May function in chromosomal DNA replication.,similarity:Belongs to the DNA2/NAM7 helicase family.,

Subcellular Location：Nucleus. Mitochondrion. Was initially reported to be exclusively mitochondrial (PubMed:18995831). However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465). .

Expression： Bone marrow,Colon,Duodenum,Lymph,