Target：DNA pol ζ

Fields：Platinum drug resistance;Fanconi anemia pathway

Gene Name：REV3L

Protein Name：DNA polymerase zeta catalytic subunit

Human Gene Id：5980

Human Swiss Prot No：O60673

Mouse Gene Id：19714

Mouse Swiss Prot No：Q61493

Immunogen：The antiserum was produced against synthesized peptide derived from human DNA Polymerase zeta. AA range:231-280

Specificity：DNA pol ζ Polyclonal Antibody detects endogenous levels of DNA pol ζ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：REV3L;POLZ;REV3;DNA polymerase zeta catalytic subunit;Protein reversionless 3-like;REV3-like;hREV3

Molecular Weight(Da)：353kD

Background：catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,domain:Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis.,similarity:Belongs to the DNA polymerase type-B family.,subunit:Interacts with REV7.,tissue specificity:Ubiquitously expressed.,

Function：catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,domain:Its C-terminal part could serve as the catalytic domain during nucleotide polymerization, while its N-terminal part could provide sites for protein-protein interactions with other factors during translesion DNA synthesis.,similarity:Belongs to the DNA polymerase type-B family.,subunit:Interacts with REV7.,tissue specificity:Ubiquitously expressed.,

Subcellular Location：Nucleus .

Expression：Ubiquitously expressed.