Target:DHRS4
Fields:Retinol metabolism;Metabolic pathways;Peroxisome
Gene Name:DHRS4
Protein Name:Dehydrogenase/reductase SDR family member 4
Human Gene Id:10901
Human Swiss Prot No:Q9BTZ2
Mouse Swiss Prot No:Q99LB2
Immunogen:The antiserum was produced against synthesized peptide derived from human DHRS4. AA range:191-240
Specificity:DHRS4 Polyclonal Antibody detects endogenous levels of DHRS4 protein.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:DHRS4;Dehydrogenase/reductase SDR family member 4;NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase;CR;PHCR;NADPH-dependent retinol dehydrogenase/reductase;NRDR;humNRDR;Peroxisomal short-chain alcohol dehydrogenase;PSCD
Observed Band(KD):32-34kD
Background:catalytic activity:R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.,function:Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones.,miscellaneous:Inhibited by kaempferol, quercetin, genistein and myristic acid.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subcellular location:Isoform 1 is peroxisomal, while isoform 4 is not.,subunit:Homotetramer.,tissue specificity:Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoforms 5 and 6 are expressed in a few neoplastic cervical tissues.,
Function:catalytic activity:R-CHOH-R' + NADP(+) = R-CO-R' + NADPH.,function:Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones.,miscellaneous:Inhibited by kaempferol, quercetin, genistein and myristic acid.,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subcellular location:Isoform 1 is peroxisomal, while isoform 4 is not.,subunit:Homotetramer.,tissue specificity:Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protei
Subcellular Location:[Isoform 1]: Peroxisome . Isoform 4 is not peroxisomal. .; [Isoform 7]: Nucleus .
Expression:[Isoform 1]: Predominantly expressed in normal cervix (at protein level). ; [Isoform 4]: Expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). ; [Isoform 5]: Expressed in a few neoplastic cervical tissues. ; [Isoform 6]: Expressed in a few neoplastic cervical tissues. ; [Isoform 8]: High expression in liver.