Target：DGK-ζ

Fields：Glycerolipid metabolism;Glycerophospholipid metabolism;Metabolic pathways;Phosphatidylinositol signaling system;Phospholipase D signaling pathway;Choline metabolism in cancer

Gene Name：DGKZ

Protein Name：Diacylglycerol kinase zeta

Human Gene Id：8525

Human Swiss Prot No：Q13574

Mouse Swiss Prot No：Q80UP3

Immunogen：The antiserum was produced against synthesized peptide derived from human DGKZ. AA range:601-650

Specificity：DGK-ζ Polyclonal Antibody detects endogenous levels of DGK-ζ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：DGKZ;DAGK6;Diacylglycerol kinase zeta;DAG kinase zeta;Diglyceride kinase zeta;DGK-zeta

Molecular Weight(Da)：124kD

Background： The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010],

Function：catalytic activity:ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.,PTM:Phosphorylation of the MARCKS homology domain by PKC reduces nuclear accumulation of DGK-zeta.,similarity:Belongs to the eukaryotic diacylglycerol kinase family.,similarity:Contains 1 DAGKc domain.,similarity:Contains 2 ANK repeats.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Isoform 2 forms a signaling complex with RASGRP1 and HRAS.,tissue speci

Subcellular Location：Nucleus . Cytoplasm, cytosol . Cell membrane . Cell projection, lamellipodium .

Expression：Highest levels in brain, and substantial levels in skeletal muscle, heart, and pancreas. ; [Isoform 2]: Predominantly expressed in muscle.