Target：DEF3

Gene Name：RBM6

Protein Name：RNA-binding protein 6

Human Gene Id：10180

Human Swiss Prot No：P78332

Immunogen：The antiserum was produced against synthesized peptide derived from human RBM6. AA range:991-1040

Specificity：DEF-3 Polyclonal Antibody detects endogenous levels of DEF-3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：RBM6;DEF3;RNA-binding protein 6;Lung cancer antigen NY-LU-12;Protein G16;RNA-binding motif protein 6;RNA-binding protein DEF-3

Observed Band(KD)：150kD

Background：disease:Defects in RBM6 are found in non-small cell lung cancer (NSCLC) cell lines.,function:Specifically binds poly(G) RNA homopolymers in vitro.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 G-patch domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,tissue specificity:Ubiquitous in adults.,

Function：disease:Defects in RBM6 are found in non-small cell lung cancer (NSCLC) cell lines.,function:Specifically binds poly(G) RNA homopolymers in vitro.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 G-patch domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,tissue specificity:Ubiquitous in adults.,

Subcellular Location：Nucleus .

Expression：Ubiquitous in adults.