Target：Amylin

Fields：Neuroactive ligand-receptor interaction;Maturity onset diabetes of the young

Gene Name：IAPP

Protein Name：Islet amyloid polypeptide

Human Gene Id：3375

Human Swiss Prot No：P10997

Mouse Swiss Prot No：P12968

Immunogen：The antiserum was produced against synthesized peptide derived from human Amylin. AA range:1-50

Specificity：Amylin Polyclonal Antibody detects endogenous levels of Amylin protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IAPP;Islet amyloid polypeptide;Amylin;Diabetes-associated peptide;DAP;Insulinoma amyloid peptide

Observed Band(KD)：25kD

Background：islet amyloid polypeptide(IAPP) Homo sapiens This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016],

Function：disease:IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.,function:Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.,online information:Amylin entry,similarity:Belongs to the calcitonin family.,

Subcellular Location：Secreted .