Target：CYP26B1

Fields：Retinol metabolism;Metabolic pathways

Gene Name：CYP26B1 CYP26A2 P450RAI2

Protein Name：cytochrome P450, family 26, subfamily B, polypeptide 1

Human Gene Id：56603

Human Swiss Prot No：Q9NR63

Mouse Gene Id：232174

Mouse Swiss Prot No：Q811W2

Rat Swiss Prot No：G3V7X8

Immunogen：Synthetic peptide from human protein at AA range: 391-440

Specificity：The antibody detects endogenous CYP26B1 protein

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000, ELISA 1:10000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CYP26B1 CYP26A2 P450RAI2

Observed Band(KD)：60kD

Background：cytochrome P450 family 26 subfamily B member 1(CYP26B1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013],

Function：cofactor:Heme group.,enzyme regulation:Has a preferred activity toward the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA.,function:Plays a key role in retinoic acid metabolism. Involved in the specific inactivation of all-trans-retinoic acid (RA). Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA.,induction:By retinoic acid.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Highly expressed in brain, particularly in the cerebellum and pons.,

Subcellular Location：Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .

Expression：Highly expressed in brain, particularly in the cerebellum and pons.