Target：CstF-64

Fields：mRNA surveillance pathway

Gene Name：CSTF2

Protein Name：Cleavage stimulation factor subunit 2

Human Gene Id：1478

Human Swiss Prot No：P33240

Mouse Gene Id：108062

Mouse Swiss Prot No：Q8BIQ5

Immunogen：The antiserum was produced against synthesized peptide derived from human CSTF2. AA range:11-60

Specificity：CstF-64 Polyclonal Antibody detects endogenous levels of CstF-64 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CSTF2;Cleavage stimulation factor subunit 2;CF-1 64 kDa subunit;Cleavage stimulation factor 64 kDa subunit;CSTF 64 kDa subunit;CstF-64

Observed Band(KD)：60kD

Background： This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008],

Function：function:One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs.,induction:Up-regulated during the G0 to S phase transition.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF2 directly interacts with CSTF3, SYMPK and RPO2TC1. Interacts with HSF1 in heat-stressed cells. Interacts with FIP1L1.,

Subcellular Location：Nucleus . Localized with DDX1 in cleavage bodies.

Expression： Kidney,Ovary,