Target：CstF-50
Fields：mRNA surveillance pathway
Gene Name：CSTF1
Protein Name：Cleavage stimulation factor subunit 1
Human Gene Id：1477
Human Swiss Prot No：Q05048
Mouse Gene Id：67337
Mouse Swiss Prot No：Q99LC2
Rat Gene Id：311670
Rat Swiss Prot No：Q5BJQ6
Immunogen：The antiserum was produced against synthesized peptide derived from human CSTF1. AA range:1-50
Specificity：CstF-50 Polyclonal Antibody detects endogenous levels of CstF-50 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CSTF1;Cleavage stimulation factor subunit 1;CF-1 50 kDa subunit;Cleavage stimulation factor 50 kDa subunit;CSTF 50 kDa subunit;CstF-50
Observed Band(KD)：48kD
Background： This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008],
Function：domain:N-terminus mediates homodimerization.,domain:The WD6 domain is required for interaction with BARD1. WD domains are responsible for interaction with CSTF3.,function:One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.,PTM:The N-terminus is blocked.,similarity:Contains 6 WD repeats.,subunit:Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts directly with CSTF3. Interacts with BARD1.,
Subcellular Location：Nucleus .
Expression： Muscle,Testis,
