Target：CROT

Fields：Peroxisome

Gene Name：CROT

Protein Name：Peroxisomal carnitine O-octanoyltransferase

Human Gene Id：54677

Human Swiss Prot No：Q9UKG9

Mouse Gene Id：74114

Mouse Swiss Prot No：Q9DC50

Rat Gene Id：83842

Rat Swiss Prot No：P11466

Immunogen：Synthesized peptide derived from CROT . at AA range: 190-270

Specificity：CROT Polyclonal Antibody detects endogenous levels of CROT protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CROT;COT;Peroxisomal carnitine O-octanoyltransferase;COT

Observed Band(KD)：72kD

Background： This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Jan 2009],

Function：catalytic activity:Octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine.,function:Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl-CoA, to its corresponding carnitine ester.,pathway:Lipid metabolism; fatty acid beta-oxidation.,similarity:Belongs to the carnitine/choline acetyltransferase family.,subunit:Monomer.,

Subcellular Location：Peroxisome .

Expression： Brain,Skin,