Target：CNOT7
Fields：RNA degradation
Gene Name：CNOT7
Protein Name：CCR4-NOT transcription complex subunit 7
Human Gene Id：29883
Human Swiss Prot No：Q9UIV1
Mouse Gene Id：18983
Mouse Swiss Prot No：Q60809
Immunogen：The antiserum was produced against synthesized peptide derived from human CNOT7. AA range:10-59
Specificity：CNOT7 Polyclonal Antibody detects endogenous levels of CNOT7 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CNOT7;CAF1;CCR4-NOT transcription complex subunit 7;BTG1-binding factor 1;CCR4-associated factor 1;CAF-1
Observed Band(KD)：36kD
Background：CCR4-NOT transcription complex subunit 7(CNOT7) Homo sapiens The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016],
Function：function:Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.,similarity:Belongs to the CAF1 family.,subunit:Interacts with TOB1.,
Subcellular Location：Nucleus. Cytoplasm, P-body . NANOS2 promotes its localization to P-body. .
Expression： Embryo,Lymph,Placenta,Prostate,Testis,
