Target：KPCD3

Fields：Rap1 signaling pathway;Aldosterone synthesis and secretion;Chemical carcinogenesis - reactive oxygen species

Gene Name：PRKD3 EPK2 PRKCN

Protein Name：Serine/threonine-protein kinase D3 (EC 2.7.11.13) (Protein kinase C nu type) (Protein kinase EPK2) (nPKC-nu)

Human Gene Id：23683

Human Swiss Prot No：O94806

Mouse Swiss Prot No：Q8K1Y2

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：KPCD3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：97kD

Background： This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Calcium-independent, phospholipid-dependent, serine- and threonine-specific kinase. Upon diacylglycerol-activation, phosphorylates a range of cellular proteins. Also serves as the receptor for phorbol esters, a class of tumor promoters.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,tissue specificity:Ubiquitous.,

Subcellular Location：Cytoplasm . Membrane . Translocation to the cell membrane is required for kinase activation.

Expression：Ubiquitous.