Target：GABAA Rβ2

Fields：Neuroactive ligand-receptor interaction;Retrograde endocannabinoid signaling;Serotonergic synapse;GABAergic synapse;Morphine addiction;Nicotine addiction

Gene Name：GABRB2

Protein Name：Gamma-aminobutyric acid receptor subunit beta-2

Human Gene Id：2561

Human Swiss Prot No：P47870

Mouse Gene Id：14401

Mouse Swiss Prot No：P63137

Rat Gene Id：25451

Rat Swiss Prot No：P63138

Immunogen：The antiserum was produced against synthesized peptide derived from human GABAA Rbeta2. AA range:382-431

Specificity：GABAA Rβ2 Polyclonal Antibody detects endogenous levels of GABAA Rβ2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GABRB2;Gamma-aminobutyric acid receptor subunit beta-2;GABA(A) receptor subunit beta-2

Molecular Weight(Da)：55kD

Background： The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008],

Function：function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1.,

Subcellular Location：Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane .

Expression：Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.