Target：KLF12

Gene Name：KLF12

Protein Name：Krueppel-like factor 12

Human Gene Id：11278

Human Swiss Prot No：Q9Y4X4

Mouse Gene Id：16597

Mouse Swiss Prot No：O35738

Immunogen：Synthesized peptide derived from the Internal region of human KLF12.

Specificity：KLF12 Polyclonal Antibody detects endogenous levels of KLF12 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：KLF12;AP2REP;HSPC122;Krueppel-like factor 12;Transcriptional repressor AP-2rep

Observed Band(KD)：44kD

Background： Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Function：function:Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,

Subcellular Location：Nucleus.

Expression： Brain,Hypothalamus,Umbilical cord blood,