Target：KIRR2

Gene Name：KIRREL2 NEPH3 UNQ5827/PRO19646

Protein Name：Kin of IRRE-like protein 2 (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3)

Human Gene Id：84063

Human Swiss Prot No：Q6UWL6

Mouse Swiss Prot No：Q7TSU7

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：KIRR2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：77kD

Background： This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016],

Function：similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with C-terminus of NPHS2/podocin.,tissue specificity:Highly expressed in beta-cells of the pancreatic islets.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Localized along the sites of the cell contacts. Colocalizes with E-Cadherin and beta-catenin. .

Expression：Highly expressed in beta-cells of the pancreatic islets.