Target：KIRR1

Gene Name：KIRREL KIRREL1 NEPH1

Protein Name：Kin of IRRE-like protein 1 (Kin of irregular chiasm-like protein 1) (Nephrin-like protein 1)

Human Gene Id：55243

Human Swiss Prot No：Q96J84

Mouse Swiss Prot No：Q80W68

Rat Swiss Prot No：Q6X936

Immunogen：Synthesized peptide derived from part region of human protein AA range: 166-216

Specificity：KIRR1 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：83kD

Background： NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).[supplied by OMIM, Mar 2008],

Function：function:Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1.,PTM:Phosphorylation probably regulates the interaction with NSH2.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Predominantly located at podocyte slit diaphragm.,subunit:Interacts with NPHS1/nephrin, TJP1/ZO-1 and C-terminus of NPHS2/podocin.,tissue specificity:Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Predominantly located at podocyte slit diaphragm.

Expression：Abundantly expressed in kidney. Specifically expressed in podocytes of kidney glomeruli.