Target：Gads

Fields：T cell receptor signaling pathway

Gene Name：GRAP2

Protein Name：GRB2-related adapter protein 2

Human Gene Id：9402

Human Swiss Prot No：O75791

Mouse Swiss Prot No：O89100

Immunogen：The antiserum was produced against synthesized peptide derived from human GRAP2. AA range:121-170

Specificity：Gads Polyclonal Antibody detects endogenous levels of Gads protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GRAP2;GADS;GRB2L;GRID;GRB2-related adapter protein 2;Adapter protein GRID;GRB-2-like protein;GRB2L;GRBLG;GRBX;Grf40 adapter protein;Grf-40;Growth factor receptor-binding protein;Hematopoietic cell-associated adapter protein Grp

Observed Band(KD)：38kD

Background： This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014],

Function：function:Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc.,similarity:Belongs to the GRB2/sem-5/DRK family.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with phosphorylated LIME1 upon TCR activation (By similarity). Interacts with phosphorylated LAT and LAX1 upon TCR activation. Interacts with SHB.,

Subcellular Location：Nucleus . Cytoplasm . Endosome .

Expression： Blood,Lung,Platelet,Spleen,T-cell,Thymus,