Target：GABAA Rγ1

Fields：Neuroactive ligand-receptor interaction;Retrograde endocannabinoid signaling;GABAergic synapse;Morphine addiction;Nicotine addiction

Gene Name：GABRG1

Protein Name：Gamma-aminobutyric acid receptor subunit gamma-1

Human Gene Id：2565

Human Swiss Prot No：Q8N1C3

Mouse Gene Id：14405

Mouse Swiss Prot No：Q9R0Y8

Rat Gene Id：140674

Rat Swiss Prot No：P23574

Immunogen：The antiserum was produced against synthesized peptide derived from human GABRG1. AA range:11-60

Specificity：GABAA Rγ1 Polyclonal Antibody detects endogenous levels of GABAA Rγ1 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GABRG1;Gamma-aminobutyric acid receptor subunit gamma-1;GABA(A) receptor subunit gamma-1

Observed Band(KD)：54kD

Background： The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq, Jul 2008],

Function：function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,miscellaneous:This subunit carries the benzodiazepine binding site.,online information:Forbidden fruit - Issue 56 of March 2005,PTM:May be palmitoylated.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,

Subcellular Location：Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Expression： Amygdala,Brain,