Target：IPMK

Fields：Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system

Gene Name：IPMK

Protein Name：Inositol polyphosphate multikinase

Human Gene Id：253430

Human Swiss Prot No：Q8NFU5

Mouse Gene Id：69718

Mouse Swiss Prot No：Q7TT16

Rat Gene Id：171458

Rat Swiss Prot No：Q99NI4

Immunogen：The antiserum was produced against synthesized peptide derived from human IPMK. AA range:311-360

Specificity：IPMK Polyclonal Antibody detects endogenous levels of IPMK protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：IPMK;IMPK;Inositol polyphosphate multikinase;Inositol 1;3,4,6-tetrakisphosphate 5-kinase

Observed Band(KD)：47kD

Background： This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010],

Function：catalytic activity:ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.,catalytic activity:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate.,function:Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4).,similarity:Belongs to the inositol phosphokinase (IPK) family.,tissue specificity:Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.,

Subcellular Location：Nucleus .

Expression：Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.