Target：iPLA2γ

Gene Name：PNPLA8

Protein Name：Calcium-independent phospholipase A2-gamma

Human Gene Id：50640

Human Swiss Prot No：Q9NP80

Mouse Gene Id：67452

Mouse Swiss Prot No：Q8K1N1

Immunogen：The antiserum was produced against synthesized peptide derived from human PNPLA8. AA range:691-740

Specificity：iPLA2γ Polyclonal Antibody detects endogenous levels of iPLA2γ protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PNPLA8;IPLA22;IPLA2G;BM-043;Calcium-independent phospholipase A2-gamma;Intracellular membrane-associated calcium-independent phospholipase A2 gamma;iPLA2-gamma;PNPLA-gamma;Patatin-like phospholipase domain-containing protein 8;iPLA

Observed Band(KD)：88kD

Background： This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2015],

Function：catalytic activity:2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.,enzyme regulation:Inhibited by E-6-bromomethylene-3-1-naphthalenyl-2H-tetrahydropyran-2-one (BEL).,function:Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids.,similarity:Contains 1 patatin domain.,tissue specificity:Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.,

Subcellular Location：Endoplasmic reticulum membrane ; Single-pass membrane protein . Mitochondrion membrane ; Single-pass membrane protein . Peroxisome membrane ; Single-pass membrane protein .

Expression：Expressed in parenchymal tissues including heart, skeletal muscle, placenta, brain, liver and pancreas. Also expressed in bronchial epithelial cells and kidney. Highest expression is observed in skeletal muscle and heart.