Target：InsP5 2-kinase
Fields：Inositol phosphate metabolism;Metabolic pathways;Phosphatidylinositol signaling system
Gene Name：IPPK
Protein Name：Inositol-pentakisphosphate 2-kinase
Human Gene Id：64768
Human Swiss Prot No：Q9H8X2
Mouse Gene Id：75678
Mouse Swiss Prot No：Q6P1C1
Rat Gene Id：306808
Rat Swiss Prot No：Q5PXE9
Immunogen：The antiserum was produced against synthesized peptide derived from human IPPK. AA range:11-60
Specificity：InsP5 2-kinase Polyclonal Antibody detects endogenous levels of InsP5 2-kinase protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：IPPK;C9orf12;Inositol-pentakisphosphate 2-kinase;IPK1 homolog;Inositol-1;3,4,5,6-pentakisphosphate 2-kinase;Ins(1,3,4,5,6)P5 2-kinase;InsP5 2-kinase
Observed Band(KD)：56kD
Background： The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010],
Function：catalytic activity:ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.,domain:The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.,function:Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.,similarity:Belongs to the IPK1 type 2 family.,tissue specificity:Ubiquitously expressed, with high expression in heart, brain, testis and placenta.,
Subcellular Location：Cytoplasm . Nucleus .
Expression：Ubiquitously expressed, with high expression in heart, brain, testis and placenta.
