Target：IP3KA

Fields：Inositol phosphate metabolism;Metabolic pathways;Calcium signaling pathway;Phosphatidylinositol signaling system

Gene Name：ITPKA

Protein Name：Inositol-trisphosphate 3-kinase A

Human Gene Id：3706

Human Swiss Prot No：P23677

Mouse Gene Id：228550

Mouse Swiss Prot No：Q8R071

Rat Gene Id：81677

Rat Swiss Prot No：P17105

Immunogen：The antiserum was produced against synthesized peptide derived from human IP3KA. AA range:396-445

Specificity：IP3KA Polyclonal Antibody detects endogenous levels of IP3KA protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ITPKA;Inositol-trisphosphate 3-kinase A;Inositol 1;4,5-trisphosphate 3-kinase A;IP3 3-kinase A;IP3K A;InsP 3-kinase A

Observed Band(KD)：52kD

Background： Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011],

Function：catalytic activity:ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.,enzyme regulation:IP3K is activated by calmodulin.,similarity:Belongs to the inositol phosphokinase (IPK) family.,

Subcellular Location：Cytoplasm, cytoskeleton .

Expression：Expressed in brain.