Target：FOLR3

Fields：Antifolate resistance;Endocytosis

Gene Name：FOLR3

Protein Name：Folate receptor gamma (FR-gamma) (Folate receptor 3)

Human Gene Id：2352

Human Swiss Prot No：P41439

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：FOLR3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：26kD

Background： This gene encodes a member of the folate receptor (FOLR) family of proteins, which have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Expression of this gene may be elevated in ovarian and primary peritoneal carcinoma. This gene is present in a gene cluster on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015],

Function：function:Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate.,PTM:Eight disulfide bonds are present.,similarity:Belongs to the folate receptor family.,tissue specificity:Spleen, thymus, bone marrow, ovarian carcinoma, and uterine carcinoma.,

Subcellular Location：Secreted.

Expression：Spleen, thymus, bone marrow, ovarian carcinoma, and uterine carcinoma.