Target：FOLR2

Fields：Antifolate resistance;Endocytosis

Gene Name：FOLR2

Protein Name：Folate receptor beta (FR-beta) (Folate receptor 2) (Folate receptor, fetal/placental) (Placental folate-binding protein) (FBP)

Human Gene Id：2350

Human Swiss Prot No：P14207

Mouse Swiss Prot No：Q05685

Immunogen：Synthesized peptide derived from part region of human protein

Specificity：FOLR2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：28kD

Background： The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

Function：function:Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.,PTM:Eight disulfide bonds are present.,PTM:N-glycosylated.,similarity:Belongs to the folate receptor family.,tissue specificity:Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.,

Subcellular Location：Cell membrane; Lipid-anchor, GPI-anchor. Secreted .

Expression：Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.