Target：GABAA Rα6

Fields：Neuroactive ligand-receptor interaction;Retrograde endocannabinoid signaling;GABAergic synapse;Taste transduction;Morphine addiction;Nicotine addiction

Gene Name：GABRA6

Protein Name：Gamma-aminobutyric acid receptor subunit alpha-6

Human Gene Id：2559

Human Swiss Prot No：Q16445

Mouse Gene Id：14399

Mouse Swiss Prot No：P16305

Rat Gene Id：29708

Rat Swiss Prot No：P30191

Immunogen：The antiserum was produced against synthesized peptide derived from human GABRA6. AA range:61-110

Specificity：GABAA Rα6 Polyclonal Antibody detects endogenous levels of GABAA Rα6 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GABRA6;Gamma-aminobutyric acid receptor subunit alpha-6;GABA(A) receptor subunit alpha-6

Observed Band(KD)：51kD

Background： GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008],

Function：function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,

Subcellular Location：Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Expression： Cerebellum,