Target：GABA A Receptor α4

Fields：Neuroactive ligand-receptor interaction;Retrograde endocannabinoid signaling;GABAergic synapse;Taste transduction;Morphine addiction;Nicotine addiction

Gene Name：GABRA4

Protein Name：Gamma-aminobutyric acid receptor subunit alpha-4

Human Gene Id：2557

Human Swiss Prot No：P48169

Mouse Gene Id：14397

Mouse Swiss Prot No：Q9D6F4

Rat Gene Id：140675

Rat Swiss Prot No：P28471

Immunogen：The antiserum was produced against synthesized peptide derived from human GABRA4. AA range:81-130

Specificity：GABAA Rα4 Polyclonal Antibody detects endogenous levels of GABAA Rα4 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：GABRA4;Gamma-aminobutyric acid receptor subunit alpha-4;GABA(A) receptor subunit alpha-4

Observed Band(KD)：60kD

Background： Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011],

Function：function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,induction:The alpha4 beta2 gamma 2L receptor is not repressed by diazepam.,online information:Forbidden fruit - Issue 56 of March 2005,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,

Subcellular Location：Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Expression： Brain,Brain cortex,