Target：FABP6

Fields：PPAR signaling pathway

Gene Name：FABP6 ILBP ILLBP

Protein Name：Gastrotropin (GT) (Fatty acid-binding protein 6) (Ileal lipid-binding protein) (ILBP) (Intestinal 15 kDa protein) (I-15P) (Intestinal bile acid-binding protein) (I-BABP)

Human Gene Id：2172

Human Swiss Prot No：P51161

Mouse Swiss Prot No：P51162

Rat Swiss Prot No：P80020

Immunogen：Synthesized peptide derived from human protein . at AA range: 30-110

Specificity：FABP6 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：14kD

Background： This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008],

Function：domain:Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.,function:Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins.,similarity:Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.,

Subcellular Location：[Isoform 1]: Cytoplasm . Membrane; Peripheral membrane protein ; Cytoplasmic side .; [Isoform 2]: Cytoplasm . Localized close to nucleus on the apical side of both normal and neoplastic cells. .

Expression：Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level).