Target：NPAS4

Gene Name：NPAS4

Protein Name：Neuronal PAS domain-containing protein 4

Human Gene Id：266743

Human Swiss Prot No：Q8IUM7

Mouse Gene Id：225872

Mouse Swiss Prot No：Q8BGD7

Rat Gene Id：266734

Rat Swiss Prot No：Q8CJH6

Immunogen：The antiserum was produced against synthesized peptide derived from human NPAS4. AA range:603-652

Specificity：NPAS4 Polyclonal Antibody detects endogenous levels of NPAS4 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NPAS4;BHLHE79;NXF;PASD10;Neuronal PAS domain-containing protein 4;Neuronal PAS4;Class E basic helix-loop-helix protein 79;bHLHe79;HLH-PAS transcription factor NXF;PAS domain-containing protein 10

Molecular Weight(Da)：87kD

Background： NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008],

Function：function:Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with ARNT.,tissue specificity:Brain.,

Subcellular Location：Nucleus .

Expression：Brain.