Target：NPAS2

Fields：Circadian rhythm

Gene Name：NPAS2

Protein Name：Neuronal PAS domain-containing protein 2

Human Gene Id：4862

Human Swiss Prot No：Q99743

Mouse Swiss Prot No：P97460

Immunogen：Synthesized peptide derived from NPAS2 . at AA range: 340-420

Specificity：NPAS2 Polyclonal Antibody detects endogenous levels of NPAS2 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NPAS2;BHLHE9;MOP4;PASD4;Neuronal PAS domain-containing protein 2;Neuronal PAS2;Basic-helix-loop-helix-PAS protein MOP4;Class E basic helix-loop-helix protein 9;bHLHe9;Member of PAS protein 4;PAS domain-containing protein 4

Observed Band(KD)：91kD

Background： The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008],

Function：function:BMAL1-NPAS2 heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.,polymorphism:Variants in NPAS2 show a susceptibility to seasonal affective disorder (SAD) [MIM:608516]. SAD is a depressive condition resulting from seasonal changes, and with diurnal preference.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK or NPAS2 is required for E-box-dependent t

Subcellular Location：Nucleus .

Expression： Human lung,Lung,