Target：NNTM

Fields：Nicotinate and nicotinamide metabolism;Metabolic pathways

Gene Name：NNT

Protein Name：NAD(P) transhydrogenase, mitochondrial (EC 1.6.1.2) (Nicotinamide nucleotide transhydrogenase) (Pyridine nucleotide transhydrogenase)

Human Gene Id：23530

Human Swiss Prot No：Q13423

Mouse Swiss Prot No：Q61941

Immunogen：Synthesized peptide derived from human protein . at AA range: 240-320

Specificity：NNTM Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：119kD

Background： This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. [provided by RefSeq, Sep 2016],

Function：catalytic activity:NADPH + NAD(+) = NADP(+) + NADH.,function:The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.,similarity:In the C-terminal section; belongs to the PNT beta subunit family.,similarity:In the N-terminal section; belongs to the AlaDH/PNT family.,subunit:Homodimer.,

Subcellular Location：Mitochondrion inner membrane ; Multi-pass membrane protein ; Matrix side .

Expression：Widely expressed with expression most readily detectable in adrenal, heart, kidney, thyroid and adipose tissues.