Target：NKRF
Gene Name：NKRF ITBA4 NRF
Protein Name：NF-kappa-B-repressing factor (NFkB-repressing factor) (Protein ITBA4) (Transcription factor NRF)
Human Gene Id：55922
Human Swiss Prot No：O15226
Mouse Swiss Prot No：Q8BY02
Immunogen：Synthesized peptide derived from human protein . at AA range: 550-630
Specificity：NKRF Polyclonal Antibody detects endogenous levels of protein.
Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000 ELISA 1:5000-20000
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Observed Band(KD)：75kD
Background： This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],
Function：function:Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.,similarity:Contains 1 G-patch domain.,similarity:Contains 1 R3H domain.,subunit:Interacts with NF-kappa-B.,tissue specificity:Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.,
Subcellular Location：Nucleus, nucleolus .
Expression：Widely and constitutively expressed (PubMed:10562553). Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney (PubMed:10562553).
