Target：NKIAMRE

Gene Name：CDKL3

Protein Name：Cyclin-dependent kinase-like 3

Human Gene Id：51265

Human Swiss Prot No：Q8IVW4

Mouse Swiss Prot No：Q8BLF2

Immunogen：The antiserum was produced against synthesized peptide derived from human CDKL3. AA range:291-340

Specificity：NKIAMRE Polyclonal Antibody detects endogenous levels of NKIAMRE protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CDKL3;NKIAMRE;Cyclin-dependent kinase-like 3;Serine/threonine-protein kinase NKIAMRE

Observed Band(KD)：67kD

Background： The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],

Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The [NKR]KIAxRE motif seems to be a cyclin-binding region.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,

Subcellular Location：Cytoplasm .

Expression： Fetal heart,Testis,