Target：NGEP
Gene Name：ANO7
Protein Name：Anoctamin-7
Human Gene Id：50636
Human Swiss Prot No：Q6IWH7
Mouse Swiss Prot No：Q14AT5
Immunogen：The antiserum was produced against synthesized peptide derived from human TM16G. AA range:881-930
Specificity：NGEP Polyclonal Antibody detects endogenous levels of NGEP protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：ANO7;NGEP;PCANAP5;TMEM16G;Anoctamin-7;Dresden transmembrane protein of the prostate;D-TMPP;IPCA-5;New gene expressed in prostate;Prostate cancer-associated protein 5;Transmembrane protein 16G
Observed Band(KD)：105kD
Background： This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011],
Function：caution:It is uncertain whether Met-1 or Met-55 is the initiator.,function:May act as a calcium-activated chloride channel. May play a role in cell-cell interactions.,induction:Up-regulated by androgen.,similarity:Belongs to the anoctamin family.,subcellular location:Concentrates at sites of cell-cell contact.,tissue specificity:Specifically expressed in epithelial cells of the prostate (at protein level).,
Subcellular Location：[Isoform 1]: Cell membrane ; Multi-pass membrane protein . Cell junction . Endoplasmic reticulum . Concentrates at sites of cell-cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604. .; [Isoform 2]: Cytoplasm, cytosol .
Expression：Specifically expressed in epithelial cells of the prostate (at protein level).
