Target：ADT2

Fields：Calcium signaling pathway;cGMP-PKG signaling pathway;Necroptosis;Cellular senescence;Neutrophil extracellular trap formation;Alzheimer disease;Parkinson disease;Huntington disease;Spinocerebellar ataxia;Prion disease;Pathways of neurodegeneration - multiple diseases;Influenza A;Human T-cell leukemia virus 1 infection;Chemical carcinogenesis - reactive oxygen species;Diabetic cardiomyopathy

Gene Name：SLC25A5 ANT2

Protein Name：ADP/ATP translocase 2 (ADP,ATP carrier protein 2) (ADP,ATP carrier protein, fibroblast isoform) (Adenine nucleotide translocator 2) (ANT 2) (Solute carrier family 25 member 5)

Human Gene Id：292

Human Swiss Prot No：P05141

Mouse Swiss Prot No：P51881

Rat Swiss Prot No：Q09073

Immunogen：Synthesized peptide derived from human protein . at AA range: 40-120

Specificity：ADT2 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500-2000 ELISA 1:5000-20000

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：32kD

Background： This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Suppressed expression of this gene has been shown to induce apoptosis and inhibit tumor growth. The human genome contains several non-transcribed pseudogenes of this gene.[provided by RefSeq, Jun 2013],

Function：function:Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.,miscellaneous:The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.,similarity:Belongs to the mitochondrial carrier family.,similarity:Contains 3 Solcar repeats.,subunit:Homodimer. Interacts with HIV-1 Vpr.,

Subcellular Location：Mitochondrion inner membrane ; Multi-pass membrane protein . Membrane ; Multi-pass membrane protein . May localize to non-mitochondrial membranes. .

Expression：Expressed in erythrocytes (at protein level).