Target：Nectin 3

Fields：Cell adhesion molecules;Adherens junction

Gene Name：PVRL3

Protein Name：Poliovirus receptor-related protein 3

Human Gene Id：25945

Human Swiss Prot No：Q9NQS3

Mouse Gene Id：58998

Mouse Swiss Prot No：Q9JLB9

Immunogen：The antiserum was produced against synthesized peptide derived from the Internal region of human PVRL3. AA range:311-360

Specificity：Nectin 3 Polyclonal Antibody detects endogenous levels of Nectin 3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PVRL3;PRR3;Poliovirus receptor-related protein 3;CDw113;Nectin-3;CD113

Observed Band(KD)：60kD

Background： This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],

Function：function:Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR

Subcellular Location：Cell membrane ; Single-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane .

Expression：Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.