Target：Nectin 3

Fields：Cell adhesion molecules;Adherens junction

Gene Name：PVRL3

Protein Name：Poliovirus receptor-related protein 3

Human Gene Id：25945

Human Swiss Prot No：Q9NQS3

Mouse Gene Id：58998

Mouse Swiss Prot No：Q9JLB9

Immunogen：The antiserum was produced against synthesized peptide derived from human PVRL3. AA range:184-233

Specificity：Nectin 3 Polyclonal Antibody detects endogenous levels of Nectin 3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：PVRL3;PRR3;Poliovirus receptor-related protein 3;CDw113;Nectin-3;CD antigen CD113

Observed Band(KD)：61kD

Background： This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],

Function：function:Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR

Subcellular Location：Cell membrane ; Single-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane .

Expression：Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.