Target：NDUFS3

Fields：Oxidative phosphorylation;Metabolic pathways;Thermogenesis;Retrograde endocannabinoid signaling;Non-alcoholic fatty liver disease;Alzheimer disease;Parkinson disease;Amyotrophic lateral sclerosis;Huntington disease;Prion disease;Pathways of neurodegeneration - multiple diseases;Chemical carcinogenesis - reactive oxygen species;Diabetic cardiomyopathy

Gene Name：NDUFS3

Protein Name：NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 mitochondrial

Human Gene Id：4722

Human Swiss Prot No：O75489

Mouse Gene Id：68349

Mouse Swiss Prot No：Q9DCT2

Immunogen：The antiserum was produced against synthesized peptide derived from human NDUFS3. AA range:117-166

Specificity：NDUFS3 Polyclonal Antibody detects endogenous levels of NDUFS3 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：NDUFS3;NADH dehydrogenase [ubiquinone] iron-sulfur protein 3; mitochondrial;Complex I-30kD;CI-30kD;NADH-ubiquinone oxidoreductase 30 kDa subunit

Observed Band(KD)：40kD

Background： This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009],

Function：catalytic activity:NADH + acceptor = NAD(+) + reduced acceptor.,catalytic activity:NADH + ubiquinone = NAD(+) + ubiquinol.,function:Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.,similarity:Belongs to the complex I 30 kDa subunit family.,subunit:Mammalian complex I is composed of 45 different subunits.,

Subcellular Location：Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side .

Expression： Brain,Cajal-Retzius cell,Pituitary,Skin,Stomach mucosa,Uter