Target：NAV3

Gene Name：NAV3 KIAA0938 POMFIL1 STEERIN3

Protein Name：Neuron navigator 3 (Pore membrane and/or filament-interacting-like protein 1) (Steerin-3) (Unc-53 homolog 3) (unc53H3)

Human Gene Id：89795

Human Swiss Prot No：Q8IVL0

Mouse Swiss Prot No：Q80TN7

Immunogen：Synthesized peptide derived from human protein . at AA range: 430-510

Specificity：NAV3 Polyclonal Antibody detects endogenous levels of protein.

Formulation：Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IHC 1:50-300. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：262kD

Background： This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008],

Function：developmental stage:Expressed in fetal brain.,disease:Defects in NAV3 may be a cause of mycosis fungoides [MIM:254400]; a malignant T-cell lymphoma of the skin.,disease:Defects in NAV3 may be a cause of Sezary syndrome, a malignant T-cell lymphoma of the skin.,function:May regulate IL2 production by T-cells. May be involved in neuron regeneration.,similarity:Belongs to the Nav/unc-53 family.,similarity:Contains 1 CH (calponin-homology) domain.,tissue specificity:Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.,

Subcellular Location：Nucleus outer membrane .

Expression：Highly expressed in brain. Expressed at low levels in heart and placenta. Present in activated T-cells but not in resting T-cells (at protein level). Down-regulated in primary neuroblastoma.